IDENTIFICATION OF THE NEED FOR THE EVALUATION OF NEW CHEMICAL ENTITIES AND MODERN CHEMISTRY INCLUSION
Pujari Abhijeet Ashok
Research Scholar, Faculty of Chemistry, OPJS University, Churu, Rajasthan
Dr. Kailas Narayan Sonune
Research Supervisor, Faculty of Chemistry, OPJS University, Churu, Rajasthan
Download PDFAbstract
Every plant is usually recognized by its personal diverse healing houses credited to energetic bioactive molecule. In the contemporary program of medication, natural drug substances will be announced to become essential and include significant functions. Their beneficial role was first validated by the existence of their bioactive substances. Credited to disease-inhibiting features, they are incredibly beneficial as natural prescription drugs, offer fundamental bioactive substances that will be much less harmful and even more successful, and provide natural and chemical substance ways of changes and removal of natural products into powerful drug. This paper overviews the need of the discovery of new chemical entities and focusing over the modern chemistry developments.
Keywords: NCE; drug discovery; click chemistry; combinational chemistry
- Benhenda, Mostapha. 'ChemGAN challenge for drug discovery: can AI reproduce natural chemical diversity?.' arXiv preprint arXiv:1708.08227 (2017).
- Yao, Hong, et al. 'The structural modification of natural products for novel drug discovery.' Expert opinion on drug discovery 12.2 (2017): 121-140.
- Zhang, Mingzi M., et al. 'Using natural products for drug discovery: the impact of the genomics era.' Expert opinion on drug discovery 12.5 (2017): 475-487
- Cheuka, Peter Mubanga, et al. 'The role of natural products in drug discovery and development against neglected tropical diseases.' Molecules 22.1 (2017): 58.
- Rodrigues, Tiago. 'Harnessing the potential of natural products in drug discovery from a cheminformatics vantage point.' Organic & biomolecular chemistry 15.44 (2017): 9275-9282.
- Altmann, Karl-Heinz. 'Drugs from the oceans: Marine natural products as leads for drug discovery.' CHIMIA International Journal for Chemistry 71.10 (2017): 646-652.
- Dong, Maryline, Bernhard Pfeiffer, and Karl-Heinz Altmann. 'Recent developments in natural product-based drug discovery for tuberculosis.' Drug discovery today 22.3 (2017): 585-591.
- Blockley, Alix, et al. 'Symbiotic microbes from marine invertebrates: driving a new era of natural product drug discovery.' Diversity 9.4 (2017): 49.
- Herrmann, Jennifer, Jan Rybniker, and Rolf Müller. 'Novel and revisited approaches in antituberculosis drug discovery.' Current opinion in biotechnology 48 (2017): 94-101.
- Baunthiyal, Mamta, Vijayata Singh, and Sushmita Dwivedi. 'Insights of antioxidants as molecules for drug discovery.' International Journal of Pharmacology 13.7 (2017): 874-889.
- Mahapatra, Debarshi Kar, and Sanjay Kumar Bharti, eds. Handbook of research on medicinal chemistry: innovations and methodologies. Taylor & Francis, 2017.
- Ariëns, Everhardus Jacobus, ed. Drug Design: Medicinal Chemistry: A Series of Monographs, Vol. 4. Vol. 4. Elsevier, 2017.
- Nelson, Kathryn M., et al. 'The essential medicinal chemistry of curcumin: miniperspective.' Journal of medicinal chemistry 60.5 (2017): 1620-1637.
- Nitsche, Christoph, et al. 'Peptide–boronic acid inhibitors of flaviviral proteases: medicinal chemistry and structural biology.' Journal of medicinal chemistry 60.1 (2017): 511-516.
- Marsault, Eric, and Mark L. Peterson, eds. Practical Medicinal Chemistry with Macrocycles: Design, Synthesis, and Case Studies. John Wiley & Sons, 2017.
- Chackalamannil, Samuel, David Rotella, and Simon Ward. Comprehensive medicinal chemistry III. Elsevier, 2017.